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Daphne Koller: ‘Digital biology is an incredible place to be right now’

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Working at the intersection of biology and computing may be the most exciting new spot for technologists at the moment.

That’s the word from Daphne Koller, the founder and chief executive officer of Insitro — the biotech company that’s raised over $243 million in the two short years since it launched.

Speaking at our virtual TechCrunch Disrupt conference, Koller, a serial entrepreneur who previously co-founded Coursera and briefly served as the chief computing officer for the Alphabet subsidiary focused on human health, Calico, views digital biology as the next big technological revolution.

“Digital biology is an incredible place to be right now,” Koller said in an interview.

It’s certainly been an incredible opportunity for Koller whose work now spans the development of treatments for potential neurological diseases and a nearer term research and development effort on hepatitis with Gilead Pharmaceuticals.

Koller’s Insitro takes its name and inspiration from the combination of two different practices in biological research — the in vitro experiments that are done on living samples in labs and the in silico experiments that are done on the computer.

By synthesizing these two disciplines Koller’s company flips the process of drug discovery on its head, the company is designed sift through massive amounts of data to search for patterns in the expression of certain conditions. Once those patterns are determined, the company can examine the pathways or mechanisms associated with that expression to determine targets for potential therapies.

Then Insitro will pursue the development of novel molecules that can be used to intervene and either reverse or stop the progression of an illness by stopping the biological mechanisms associated with it.

“We now have massive amounts of data that is truly relevant to human disease,” Koller said. “Machine learning has given us a bunch of tools to really make sense of data.”

The company can identify new patient segments, new interventions new drugs that may modulate the expression of those conditions. “We view ourselves as being on the first phase of a very long journey using machine learning,” said Koller.

Take the company’s work on hepatitis in conjunction with Gilead. There, Koller and her team were able to take a small, high-quality dataset from Gilead’s trials and identify how a disease progressed by looking at the patient data from different points in time. Looking at the progression allowed the company to identify drivers that facilitated the progression of fibrosis that causes tissue damage. Now the company is using those targets as a starting point to find modifiers that could slow down the progression of the disease. 

It comes down to using computers to understand the biology, new biotechnology to model that biology in a Petri dish, and from the different models determine the interventions that will make a difference, Koller said.

“What we’re trying to do is so different and so out of alignment with how these [pharmaceutical] companies do their work,” Koller said. “It’s trying to shift the trajectory of these companies of hundreds or thousands of people and shift the culture to a tech culture that is going to be really a challenge.”

It’s the main reason Koller launched her own company rather than joining a big pharma play, and it’s a classic example of the innovator’s dilemma and the disruptive power of technology laid out in the theories of Clayton Christensen that give the Disrupt conference its name.

“[It’s] the notion of the innovator’s dilemma and coming in with a mindset that says we’re going to do this a completely different way,” said Koller. “The drug discovery effort is becoming increasingly expensive and increasingly prone to failure and if we do this in a different way will it enable us to generate better outcomes.”

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Charge Your Phone Wirelessly With 50% off a Multifunctional LED Lamp

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Best Tech DealsBest Tech DealsThe best tech deals from around the web, updated daily.

White Wireless Charge Lamp | $18 | Amazon | Clip coupon + code ABC88699
Black Wireless Charger Lamp | $20 | Amazon | Promo code ABC88699

When you’re ready to turn in for the night, you don’t want to forget to charge your phone— especially if your mobile device doubles as your alarm clock.

With this wireless charger lamp, you can make this crucial step of your nightly routine even easier by just setting your phone on the wireless charging pad and… well, that’s all there is to it!

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Other functions include multiple lighting modes as well as a sleep timer option for auto shut-off of the light after 30 or 60 minutes.

This lamp can be yours in white for $18 if you clip the coupon on Amazon (it’s below the original $40 price) and add promo code ABC88699 at checkout.

You can snag the black version for $20 using the same code—no coupon though, sorry.

Don’t sleep on this deal! Who knows how long stock or the coupon code will last?

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Keep That Hotdish Hot With 65% Off a Luncia Casserole Carrier, Only $11 With Promo Code

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Best Home DealsBest Home DealsThe best home, kitchen, smart home, and automotive deals from around the web, updated daily.

Luncia Double-Decker Dish Carrier | $11 | Amazon | Promo code SDDU9S7F

It has been a long time since the days we could safely have a potluck or other gatherings, but we have a fantastic deal perfect for once those times return. These double-decker Luncia dish carriers can be had for 65% off when you add promo code SDDU9S7F at checkout and clip the coupon on the site (it’s just below the price). These holders fit 9″x 13″ sized baking dishes.

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That means you can insulate and keep two dishes of food warm for only $11 instead of $30. What’s more, your Luncia carrier will arrive by Christmas if you order today as a Prime member.

Just add promo code SDDU9S7F and clip the 5% off coupon to bring the price down to $11 for the blue or the grey option.

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Grab this offer while it’s still around!


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Conquer Your Pup’s Dander and Fur With $700 Off a Cobalt or Charcoal Bobsweep PetHair Plus Robot Vacuum

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Best Home DealsBest Home DealsThe best home, kitchen, smart home, and automotive deals from around the web, updated daily.

Bobsweep PetHair Plus Robot Vacuum & Mop (Cobalt) | $200 | Best Buy

Bobsweep PetHair Plus Robot Vacuum & Mop (Charcoal) | $200 | Best Buy

Allergies can be bad enough as the seasons change. Don’t let pet hair and dander add to that by vacuuming it up early and often. That chore is easier said than done— unless you have a robot vacuum to do the work for you. This lovely bright cobalt Bobsweep PetHair Plus robot vacuum and mop, only $200 today at Best Buy seems like an ideal option. That’s a whopping $700 off, by the way.

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You can get the same deal for the charcoal version of the robot vac, too. This model is not only specially made for picking up pet hair, it self docks and charges when it’s finished with the work.

It also comes with a mop attachment, so it can take care of those kitchen floors for you as well. Grab it while it’s still available for this fantastic price!

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